NMR urine analysis in recurrent urinary stones patients
Research type
Research Study
Full title
Nuclear Magnetic Resonance (NMR) Spectrometric urine analysis in recurrent renal stone forming patients-Pilot study
IRAS ID
183651
Contact name
Seshadri Sriprasad
Contact email
Sponsor organisation
Dartford and Gravesham NHS Trust
Duration of Study in the UK
1 years, 2 months, 10 days
Research summary
Recurrent urinary stones formation is a condition where patients get more than a single episode of urinary stones. Those patients often require repeated urological intervention and they are at risk of long term kidney damage if they are left untreated. The formation of recurrent urinary stones in those patients is attributed to a combination of many risk factors, For instance, the abundance - or sometimes the lack- of some chemical substances (metabolites) in their plasma or urine e.g . increased urinary levels of Calcium, Phosphate and Uric acid and decreased urinary level of Citrate and many other conditions.
Prevention of recurrent urinary stones formation is dependant in the first place on identifying each individual’s risk factors. This is carried out through a group of laboratory urinary and blood tests that will help identifying the presence of any modifiable metabolic abnormalities and hence enable the urologists to give a dietary and behavioral advice to help the risk reduction of recurrent stones. One of the important laboratory tests is the analysis of 24 hour collection of the patients'’ urine for various chemical substances as mentioned above. Despite the above mentioned measure of prevention, significant number of patients from this group will still suffer with recurrent renal stones. More understanding for the renal stone formation process is vital to help the risk reduction.
In our study we aim to use Nuclear Magnetic Resonance Spectrometry (NMR spectrometry) to analyse those patients’ urine samples and compare the results with those of the routine urine tests of the same patients. NMR spectroscopy is sensitive, highly accurate and capable of detecting a wide range of metabolites in the human urine. The aim is to discover new urinary marker(s)) that could help develop more understanding of urinary stone formation and hence help the prevention.
REC name
North West - Haydock Research Ethics Committee
REC reference
15/NW/0777
Date of REC Opinion
25 Sep 2015
REC opinion
Favourable Opinion