NITRITE-AMI

• Research type

  Research Study

• Full title

  A randomised, double-blind, placebo-controlled trial assessing the safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction

• IRAS ID

  69234

• Contact name

  Anthony Mathur

• Sponsor organisation

  Barts Health NHS Trust

• Eudract number

  2011-000721-77

• Clinicaltrials.gov Identifier

  NCT01584453

• Research summary

  Despite advances in the treatment of heart attacks such as reopening of the blocked artery (primary angioplasty), the complications and death rates from failure of the heart to pump adequately remain high. The size of the heart attack is the major determinant of these adverse outcomes. Whilst re-opening the artery allows blood to flow to the area of the heart starved of oxygen, this process also causes damage itself (??reperfusion injury?) and increases the size of the heart attack. It has been shown that nitrite protects against reperfusion injury in models of heart attack. We will therefore perform a trial to investigate whether during a heart attack, an infusion of nitrite into the damaged artery protects against reperfusion injury and reduces heart attack size

• REC name

  London - West London & GTAC Research Ethics Committee

• REC reference

  11/LO/1500

• Date of REC Opinion

  8 Nov 2011

• REC opinion

  Further Information Favourable Opinion