Nitric Oxide Synthase Inhibition on Human Atrial Electrophysiological
Research type
Research Study
Full title
Effects of Neuronal Nitric Oxide Synthase Inhibition on Human Atrial Electrophysiological Properties
IRAS ID
222879
Contact name
Paramdeep Dhillon
Contact email
Sponsor organisation
The R&D Office
Clinicaltrials.gov Identifier
17LO/1840, London-WestminsterREC
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
There is emerging evidence that abnormalities of a heart enzyme called neuronal nitric oxide synthase (nNOS) may be involved in the development of a common heart rhythm disorder called atrial fibrillation (AF). AF can cause heart failure and strokes.
We commonly perform operations (ablations) to treat AF and other rhythm disorders. At the end of an ablation procedure, there is a 40 minute waiting period to ensure there is no recurrence. We propose to test the effect of a drug, S-methyl-L-thiocitrulline (SMTC), which blocks the action of nNOS, on the electrical behaviour of the heart. We would like to confirm that nNOS is involved in AF so that new treatments can be designed to treat AF. SMTC has been used extensively in human research previously in other projects.
Participants would be recruited from those who are already due to undergo invasive cardiac electrophysiological procedures as part of their routine clinical care. All studies would be carried out at King's College Hospital NHS Foundation Trust.
Because the study will be carried out during the pre-existing waiting period, no extra procedural time is needed for this study. No specific follow up appointments are necessary.REC name
London - Westminster Research Ethics Committee
REC reference
17/LO/1840
Date of REC Opinion
29 Dec 2017
REC opinion
Further Information Favourable Opinion