Night Vision in RP
Research type
Research Study
Full title
ASSESSMENT OF SCOTOPIC FUNCTION IN ROD-CONE INHERITED RETINAL DEGENERATION
IRAS ID
237611
Contact name
Jasleen K Jolly
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
The purpose of this study is to quantify vision at low light levels using the scotopic MAIA micro perimeter in patients with rod- cone dystrophies. This is a device which can be used to assess vision at low light levels, a difficulty that patients with rod-cone dystrophies suffer with early in the disease process.
Scotopic refers to low light levels in comparison to mesopic classed as ambient lighting.
There will be 30 participants recruited.
Cohort one will consist of 20 patient participants with a confirmed diagnosis of rod-cone dystrophies. These patients will be recruited from clinic appointments or from databases where they have previously expressed an interest in being involved in research.
10 participants with no known eye disease will be recruited for the control arm, though online adverts and posters displayed in the department. Accompanying friends or relatives of patient participants can also be recruited if they satisfy the eligibility criteria.
Both cohorts will be consented for their involvement by a member of the research team. Visual acuity will be performed, followed by traditional mesopic microperimetry. Participants will then be randomised to either perform full field scotopic testing (FST) or scotopic MAIA microperimetry first. This is to ensure that fatigue, concentration and learning do not bias the results.
In the case of FST being performed first, participants will be dark adapted for 45 minutes followed by full stimulus threshold testing. A further 45 minute dark adaptation will follow and scotopic microperimetry will be performed three times to assess test-retest variability. After a further dark adaptation period of 20 minutes scotopic microperimetry will be performed thrice. All tests will be conducted on the right eye only.
A flow chart is available for ease of understanding in the protocol and patient information sheet.REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
18/WM/0086
Date of REC Opinion
3 Apr 2018
REC opinion
Favourable Opinion