NHS GGC Additional Sample Tissue Resource to Support IMID Research-I
Research type
Research Tissue Bank
IRAS ID
345251
Research summary
NHS GG&C Additional Tissue Resource to Support Immune Mediated Inflammatory Diseases Research (IMID) -I
Short form: IMID RTB
REC name
West of Scotland REC 4
REC reference
24/WS/0103
Date of REC Opinion
7 Aug 2024
REC opinion
Favourable Opinion
Data collection arrangements
The aim of the IMID RTB is to continue the collection, storage and supply a number of tissue types, which have been either prospectively or retrospectively collected, in order to facilitate and support medical research carried out by the Immunobiology section of the School of Infection & Immunity, University of Glasgow.
Where appropriate patients may be requested to donate additional blood and/or biopsy samples using the appropriate participant information sheets, participant consent form and privacy notice for the collection of the additional tissue described below.
Additional tissue types requested include:
Whole blood plus derivatives (e.g. serum, plasma, buffy coat and other blood cell fractions)
Urine
Stool
Synovial biopsy and excess synovial fluid from joint
Skin biopsy
Bowel/colon biopsy1) Fresh solid tissue may be used immediately by the research end user for their approved research study.
2) Fresh solid tissue may be aliquoted by the research end user and frozen at -20C and -80C, or ultra-low temperature (liquid nitrogen) for future use in their approved research study.
3) Solid tissue may be formalin fixed and stored as a formalin fixed paraffin block (FFPB) by the research end user for subsequent tissue sectioning and mounting on glass slides for immunohistology analyses in their approved research study.
4) Occasionally tissue micro arrays (TMAs) may also be constructed from the FFP block tissue resources.
5) Blood and tissue derivatives may be processed to extract DNA, RNA or protein extractions which may be used immediately or stored by the research end user for use in their approved research study.
6) Fresh blood may be processed to derive aliquots of serum, plasma, buffy coat, or other cell fractionations, to either be used immediately by the research end user or frozen for future use
7) Fresh blood or solid tissue may be processed to generate immortalised cell lines, or time limited primary cell cultures.Research programme
The main purpose of the tissue resource is to support the established and growing basic and translational research programme in the School of Infection & Immunity, an internationally recognised research organisation, whose specific interest is to better understand the immunological and pathogenetic pathways in a wide range of conditions organised under the umbrella of immune mediated inflammatory diseases (IMID), which includes rheumatic and musculoskeletal diseases (RMD), a collective term that covers over 200 conditions and includes a wide range of degenerative and inflammatory conditions, infection related arthritis, gout, tendon disease, and vasculitis. Furthermore, the School also researches other infectious and inflammatory mediated conditions and has an active and growing research programme which specifically investigates the pathogenesis and immune dysregulation of tendon disease; inflammatory conditions of the lung, skin, gastrointestinal tract, kidney and liver. We also have a broad research programme looking at the relationship between central and peripheral chronic fatigue and pain conditions and the peripheral inflammation associated with chronic rheumatic diseases, by looking at the roles of neurobiological factors and inflammatory factors in these conditions.
RTBTitle
NHS GG&C Additional Tissue Resource to Support Immune Mediated Inflammatory Diseases Research (IMID) -I Short form: IMID RTB
Establishment organisation
University of Glasgow, School of Infection & Immunity
Establishment organisation address
Sir Graeme Davies Building
120 University Place
Glasgow
G12 8TA