neutrophil-lymphocytic ratio vs CRP in patients diagnosed with sepsis
Research type
Research Study
Full title
comparing trends of Neutrophil-lymphocytic ratio vs C reactive protein in patients diagnosed with sepsis
IRAS ID
364825
Contact name
Nicole Mascarenhas
Contact email
Sponsor organisation
Medway Maritime Hospital
Duration of Study in the UK
0 years, 4 months, 0 days
Research summary
This study is to compare trends of Neutrophil lymphocytic ratio with total counts and c reactive protein in patients diagnosed with sepsis. Neutrophil Lymphocytic count, or NLR is the ratio of the number of neutrophils (a type of white blood cell) to that of lymphocytes (another type of white blood cell), C Reactive protein is a protein that is released in the body during sickness like infection, cancers and other illnesses that cause inflammation. White blood cells are the cells in a person’s body that helps to fight off infection. We would like to see if the trends are comparable. If NLR follows a similar trend to that of CRP, then it can be used as an alternative inflammatory marker for sepsis, reducing extra blood tests as the NLR can be calculated from a full blood count . A full blood count is a blood test that counts how many red blood cells, white blood cells and platelets; which help in clotting; are in the blood. an additional advantage is that white cell counts are more dynamic and do not lag, unlike CRP. CRP tends to have a more delayed reaction to inflammation as compared to White cell counts.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
26/LO/0140
Date of REC Opinion
4 Mar 2026
REC opinion
Favourable Opinion