Neutrophil defects and tooth loss in children

• Research type

  Research Study

• Full title

  Investigation of dental health in children affected by neutrophil defects. A clinical study.

• IRAS ID

  163884

• Contact name

  Nikos Donos

• Contact email

  n.donos@ucl.ac.uk

• Sponsor organisation

  Queen Mary University of London

• Duration of Study in the UK

  1 years, 6 months, 1 days

• Research summary

  Primary immunodeficiency diseases (PIDs) are a group of rare inherited disorders that are estimated to affect approximately 1 in 2,000 children . Such disorder include neutrophil disorders ( white blood cell disorders) which can reduce the ability for the body to defend itself from infections which can then lead on to gum disease leading to swollen gums ,loose teeth and loss of teeth. Current research activity is focused on identifying factors the increase the susceptibility of gum disease.

  The primary objective of this study is:
  To investigate presence of periodontal disease and response to periodontal treatment in children affected by neutrophil defects

  The secondary objectives of this study are:
  To investigate presence of other dental diseases in children affected by neutrophil defects
  To assess oral microbiological and inflammatory parameters in children affected by neutrophil defects

  This is a cohort study.The study population will be recruited among children attending the Great Ormand Street Hospital immunology clinic and either themselves or parents have given written informed consent to the study.

  All individuals who consent to this study will receive a basic periodontal examination (BPE) and collection of a saliva sample and plaque samples. For individuals with signs of more advanced gum disease a comprehensive full mouth periodontal probing depths assessment will be performed and periodntal treatment which includes oral hygiene advice and scaling of teeth (under local anaesthetic if needed)

  Study procedures will take approximately 30 minutes with a further 60 minutes for those with gum disease and a review which will take 30minutes therefore 1- 7 visits which will span over 8months to 12 months in total.

• REC name

  London - Hampstead Research Ethics Committee

• REC reference

  15/LO/1090

• Date of REC Opinion

  12 Oct 2015

• REC opinion

  Further Information Favourable Opinion