Neuropsychiatric symptoms in Parkinson's disease (NPS-PD)
Research type
Research Study
Full title
NEUROPSYCHIATRIC SYMPTOMS IN PARKINSON’S DISEASE
IRAS ID
349743
Contact name
Sagnik Bhattacharyya
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Individuals diagnosed with Parkinson's Disease (PD) may experience a range of non-motor symptoms that relate to their thoughts, feelings and behaviours. This can be difficult for participants and their caregivers to manage and can reduce their quality of life and increase their risk of needing to relocate to a nursing home. These risks are elevated for those who also have psychotic symptoms in PD, such as hallucinations or delusions.
This study will aim to explore the types and prevalence of neuropsychiatric symptoms in PD. Understanding which symptoms are most prevalent in this population will be helpful in understanding the clinical burden of the disease for patients and their caregivers and can direct how clinicians can help to manage this. Standardised clinical assessments evaluate neuropsychiatric symptoms such as depression, anxiety, psychosis, apathy and agitation. We aim to compare the prevalence of these symptoms in patients with Parkinson’s Disease, with and without psychosis (n=200). Participants will be eligible for the study based on validated diagnostic criteria for PD and PD Psychosis (PDP) and if they are over 40 years old and have a study partner who can answer questions about the participant. The battery of neuropsychiatric assessments should take up to four hours to complete and will be conducted with a trained researcher and the participant and their study partner either in person (at King's College London), over a telephone call or a video call (Microsoft teams). Questionnaires and consent forms will either be completed on paper forms or online. If completing online, questionnaires will still be done on paper and pen, but asked over a video call with the researcher rather than in person.
If participants agree, there will be an optional blood sample taken for future research purposes.REC name
London - Surrey Research Ethics Committee
REC reference
25/LO/0339
Date of REC Opinion
16 May 2025
REC opinion
Further Information Favourable Opinion