Neuropathic Pain in Children. version 1
Research type
Research Study
Full title
Characterisation of neuropathic pain in children: multimodal assessment and diagnosis.
IRAS ID
226141
Contact name
Suellen Walker
Contact email
Sponsor organisation
Great Ormond Street Hospital for Children NHS Foundation Trusts and UCL Institute of Child Health
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
Can patient-reported outcomes, sensory testing, and brain imaging improve the diagnosis and understanding of neuropathic pain in children?
In some children with chronic pain, pain is related to damage or diseases that affect the nerves that send pain signals. This is known as neuropathic pain. This is not well understood and can be difficult to diagnose. It can often produce unusual feelings such as sensitivity of the skin to light touch. Neuropathic pain is often severe and difficult to treat, and can affect quality of life for the child and family.
We will determine whether a questionnaire to identify neuropathic pain in adults is also useful in children. This will help paediatricians and other doctors to recognise neuropathic pain and start appropriate treatment or know when to refer children to a chronic pain clinic. We will also measure the effects of neuropathic pain on mood, sleep, and quality of life (using questionnaires); identify changes in the sensitivity of the skin to touch and other sensations (using specialised sensory tests); and determine the feasibility of brain imaging for assessing changes in the brain (using magnetic resonance imaging or MRI), in these children. This information will allow us to measure how effective different types of treatment are, and help ensure children get the most appropriate treatment or interventions to reduce pain and effects on quality of life.
This pilot study of 10-18 year olds diagnosed with neuropathic pain will involve completion of questionnaires by the child and parent, and sensory testing in the child, after their clinic appointment. For some families, there will be an additional visit for MRI. Children will be recruited from the Chronic Pain Outpatients service at Great Ormond Street Hospital NHS Trust. This research is funded by Great Ormond Street Hospital Children’s Charity.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
17/WM/0306
Date of REC Opinion
23 Aug 2017
REC opinion
Further Information Favourable Opinion