Nero Study
Research type
Research Study
Full title
Nitrite-induced redox regulation of vascular function in hypertension
IRAS ID
271274
Contact name
Una Martin
Contact email
Sponsor organisation
Head of Research Governance and Ethics
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
High blood pressure (hypertension) is a major problem worldwide. Blood pressure is created by the force of blood against the vessel, and if this pressure remains continuously high it would put extra strain on the heart and vessels. This can increase the risk of a heart attack, stroke, or even kidney disease. There are medicines available to treat high blood pressure, but this may have side effects. Therefore, it is important to investigate and develop new alternative treatments. There is a chemical called sodium nitrite that has been shown to improve the function of the blood vessel, and we have discovered a new mechanism in how sodium nitrite lowers blood pressure. We would like to test this new mechanism in biopsies and blood samples obtained from healthy volunteers and patients who suffer from high blood pressure so that we can investigate sodium nitrite as an alternative treatment for high blood pressure.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
20/SC/0045
Date of REC Opinion
4 Feb 2020
REC opinion
Favourable Opinion