Nephrogreen
Research type
Research Study
Full title
An open label cohort study assessing the near infrared fluoroscopic macro and microscopic appearances of paediatric renal parenchyma and tumours following ex-vivo injection of indocyanine green.
IRAS ID
309846
Contact name
Max Pachl
Contact email
Sponsor organisation
Birmingham Women’s & Children’s NHS Foundation Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
Fluorescent guided surgery using Indocyanine Green (ICG) is used in adult cancer operations on a routine basis to enable the surgeon to see where the border of the tumour is, or to identify lymph nodes. . The aim of this study is to see if ICG can help us identify exactly where in the kidney the tumour is located. For kidney cancer, ICG does not make the tumour fluoresce, but the inverse occurs. The normal kidney tissue fluoresces, but the tumour doesn't.
The standard approach to paediatric renal tumour is to remove the whole kidney but this difference in fluorescence may enable surgeons to remove just the tumour and leave healthy kidney tissue behind. This study aims to show exactly where the border is between fluorescence and non-fluorescence for all tumour types under the naked eye and the microscope.
It also aims to review if ICG can differentiate between nephrogenic rests, normal kidney and tumour. These are abnormal areas of renal tissue which are difficult to diagnose with current imaging techniques or on tissue biopsy. They look identical to renal tumours both on imaging and on biopsy. If ICG was able to differentiate between these areas, normal parenchyma, and tumour then this would give surgeons a huge advantage in the management of paediatric renal cancer.REC name
West of Scotland REC 1
REC reference
22/WS/0138
Date of REC Opinion
19 Oct 2022
REC opinion
Further Information Favourable Opinion