NeoRet v1.0
Research type
Research Study
Full title
NeoRet: Creating a Retinal Growth Chart for Early Life
IRAS ID
351325
Contact name
Kanmin Xue
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
1 in 3 babies born prematurely before 32 weeks is at risk of developing retinopathy of prematurity (ROP), a condition caused by abnormal growth of blood vessels in the retina. ROP is a leading cause of childhood blindness worldwide, significantly affecting their quality of life. Although early signs of ROP may appear shortly after birth, it typically does not become severe enough to require treatment until later, offering a crucial window for potential intervention. We know that oxygen therapy is a key risk factor for ROP, but the exact levels and timing of oxygen administration that increase risk remain unclear. Furthermore, the relationship between retinal blood vessel development and the maturing function of the retina in premature infants are poorly understood, making early detection and treatment of ROP challenging.
To better understand this, we propose creating a growth chart that tracks both the structural and functional development of the retina. This chart will serve as a reference tool for early detection of infant eye diseases, including ROP and potentially other retinal conditions. Through this, we aim to provide a detailed understanding of how retinal development and how oxygen levels interact and contribute to the progression of ROP.
In this study, we will monitor the structure and function of the retina over time to observe its growth and examine how factors such as age and illness influence this growth. By comparing these findings with infants’ vital signs, we aim to gain a comprehensive understanding of retinal development in premature infants and pave the way for improved early detection and targeted interventions.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
25/YH/0219
Date of REC Opinion
10 Nov 2025
REC opinion
Favourable Opinion