Native T1 Mapping in Rare Diseases
Research type
Research Study
Full title
Native T1 Mapping by Cardiovascular Resonance Imaging in Rare Diseases - A New Method to Improve Patient Care
IRAS ID
142036
Contact name
James C Moon
Contact email
Clinicaltrials.gov Identifier
Z6364106/2014/07/17, Data Protection Registration
Duration of Study in the UK
4 years, 11 months, 29 days
Research summary
Cardiovascular magnetic resonance (CMR) is an essential imaging tool with the unique advantage of non-invasive myocardial tissue assessment. Development of the CMR T1 mapping sequence has allowed quantification of biologically important properties and thus potentially the detection and tracking of important changes in the myocardium early in disease processes.
Patients with multisystem diseases, such as iron overload (primary and secondary) and Anderson-Fabry disease, can develop insidious cardiac pathology that may lead to death from heart failure or arrhythmias, therefore require early diagnosis and close monitoring.
This research will involve a series of prospective longitudinal clinical observational studies to detect myocardial disease. Participants will undergo a non-contrast CMR scan following a typical clinical protocol that allows the gold-standard measurement of function, volumes and mass assessment. In addition participants will undergo the research T1 mapping sequence adding seconds to the duration of the scan.
REC name
London - Riverside Research Ethics Committee
REC reference
14/LO/1948
Date of REC Opinion
22 Dec 2014
REC opinion
Further Information Favourable Opinion