NAFL-DM (version_1.4_2019-10-14)
Research type
Research Study
Full title
Characterising the relationship between non-alcoholic fatty liver disease and type 2 diabetes using genetic insights
IRAS ID
243720
Contact name
N/A CTRG
Contact email
Sponsor organisation
University of Oxford, Clinical Trials and Research Governance
Duration of Study in the UK
3 years, 8 months, 31 days
Research summary
The body tightly regulates sugar and fat circulating in the blood. This involves almost all organs, the liver being key. Accumulation of fat in the liver (‘NAFLD’) may reduce the liver’s ability to perform its role in this.
Diabetes occurs when the body is not able to regulate blood sugar. Diabetes, affecting about 10% of people, is the biggest risk factor for heart disease, blindness, kidney failure and lower limb amputation. It represents a huge health, social and financial burden. NAFLD is even more common than diabetes and the two occur more often together. However, it is unclear whether one causes the other, or if the cause is unrelated.
Utilising genetics of diabetes and NAFLD, I will perform state-of-the-art studies in humans to characterise the relationship between the two. This will provide new insights into the mechanisms that drive the two and highlight new strategies for treatment and prevention.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
18/SC/0495
Date of REC Opinion
6 Nov 2018
REC opinion
Further Information Favourable Opinion