MYSTIC - MRI in Intracerebral Haemorrhage
Research type
Research Study
Full title
MYSTIC - MRI Study for the Investigation of Intracerebral Haemorrhage
IRAS ID
147917
Contact name
Keith Muir
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Bleeding into the brain (brain haemorrhage) causes about 15% of strokes. While there is some immediate damage caused by bleeding, the blood also triggers a reaction in brain tissue that includes inflammation and reduced blood supply, leading to delayed damage to surrounding brain tissue over several days. There is currently no specific treatment for brain haemorrhage.
This study will use advanced brain scanning with magnetic resonance imaging (MRI), and detection of proteins in the blood (proteomics), to explore why people deteriorate after a brain haemorrhage.
The type of MRI used in this study will provide information on several different processes which may damage the brain, in order to provide a better understanding of what happens after brain haemorrhage. The blood tests (proteomic testing) will be used to complement data from the MRI scan.
We plan to include 20 patients with brain haemorrhage as they are admitted to hospital, with follow-up MRI scanning at 3-5 days. We will also take blood tests for proteomic analysis and monitor clinical progress so that we can correlate this information with the brain scans.
If we can identify those patients who are likely to deteriorate later after a brain haemorrhage, then this may allow future clinical trials of treatments intended to prevent secondary damage to target the most appropriate people. It is anticipated that information from this study will lead to larger studies to inform the design of clinical trials of treatment of brain haemorrhage.
REC name
Scotland A: Adults with Incapacity only
REC reference
15/SS/0065
Date of REC Opinion
29 Apr 2015
REC opinion
Favourable Opinion