Myocardial Work in severe Aortic Stenosis
Research type
Research Study
Full title
Can the use of echocardiography derived Myocardial Work predict outcomes in patients with severe aortic stenosis prior to transcatheter aortic valve intervention.
IRAS ID
313577
Contact name
Mohammad Alkhalil
Contact email
Sponsor organisation
Newcastle Hospital Foundation NHS Trust
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
Aortic stenosis (AS) is the most common type of valvular heart disease in the western world and more prevalent in the elderly population where one in eight people over the age of 75 years have moderate or severe AS. AS is a debilitating, degenerative form of valve disease whereby the aortic valve becomes thickened and restricted over time. As the aortic valve leaflets do not open sufficiently in people with AS, there is a risk of developing heart failure and premature death. Patients who have significant AS have considerable reduced quality of life due to symptoms such as breathlessness, chest pain and fatigue.
Myocardial work (MW) is a novel parameter developed within transthoracic echocardiography. This new technique provides a more sensitive measurement of how well the heart contracts and combines this information with resting blood pressure. MW allows for a more detailed and sensitive look at how the heart is responding to the increased demands caused by AS by the formation of pressure-strain loops of each segment heart muscle. There are no current prospective studies that evaluate whether MW in severe AS patients can predict long-term outcomes.
This study intends on evaluating MW in severe AS patients at Newcastle Hospitals prior to their already scheduled valve intervention to determine if this new measurement predicts re-hospitalisation for heart failure, heart attack, stroke and risk of premature death. An echocardiogram will also be performed following the implantation of the new prosthetic valve prior to hospital discharge to repeat MW measurements and provide details of any complications that have arose during the procedure. These patients will also receive an echocardiogram at 6 weeks and 12 months post-intervention to look at the change in MW. Patients will also be followed-up after hospital discharge every six months for up to three years.REC name
London - Chelsea Research Ethics Committee
REC reference
22/LO/0675
Date of REC Opinion
7 Nov 2022
REC opinion
Further Information Favourable Opinion