Myocardial modelling and assessment using 2D TOE echocardiography
Research type
Research Study
Full title
Myocardial modelling and assessment using 2D TOE echocardiography
IRAS ID
221714
Contact name
Stephen Large
Contact email
Sponsor organisation
Papworth Hospital
Duration of Study in the UK
0 years, 5 months, 1 days
Research summary
Hemodynamic monitoring is an important part of the management of patients with acute cardiac diseases. In a clinical setting an ideal hemodynamic monitoring procedure would be accurate, minimally invasive, readily available, operator independent, continuous and easy to use. Pressure volume loops are considered the gold standard in cardiac performance assessment however conductance catheters, the instrument by which pressure volume loops are constructed, have several disadvantages including complexity of use, cost, lack of reusability and invasiveness. There is also no agreement in the literature that their accuracy is satisfactory. The three dimensional reconstruction of the heart from two dimensional echocardiography images has been researched before however these previously presented methods require a complex clinical procedure. In a clinical setting this kind of procedure is not feasible and highly time consuming for the practitioner. Instead a method by which the three dimensional geometry of the heart can be easily ascertained from only two dimensional slices is to be investigated. This method would allow for simpler more accurate measures of cardiac performance. This research will involve taking two dimensional transoesophageal echocardiographic images of patient’s hearts in a method similar to current clinical procedure. The images will then be processed by automated software to form a three dimensional model of the heart which will in turn be used to assess cardiac function of the heart. This procedure would allow for the output of hemodynamic parameters such as cardiac output, stroke volume, ejection fraction and myocardial strain values. Using the strain values in the myocardium and knowing the cardiac output of the ventricles it will then be possible to calculate the tension generated by the myocytes in the myocardium and thus the pressure exerted on the blood which would allow for an estimation of the pressure volume characteristics of the ventricles.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
17/EE/0096
Date of REC Opinion
4 Apr 2017
REC opinion
Further Information Favourable Opinion