Myectomy outcomes in childhood hypertrophic cardiomyopathy
Research type
Research Study
Full title
Outcomes of septal reduction surgery in paediatric hypertrophic cardiomyopathy in the United Kingdom
IRAS ID
344806
Contact name
Juan Pablo Kaski
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
UCL data protection number , Z6364106/2023/10/44
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Hypertrophic cardiomyopathy (HCM) is defined as unexplained thickening of the heart muscle and is the second most common heart muscle disease presenting in childhood. In up to a third of patients, thickening of the heart muscle can cause obstruction to the blood flow out of the heart causing symptoms. Although this can often be managed with medications, in a small minority of patients, surgery is required to relieve the obstruction (left ventricular myectomy). As HCM is a rare disease, our current understanding of the outcomes of children requiring surgery is limited. This study will take advantage of the National Congenital Heart Disease (NCHDA) dataset to describe the early outcomes of left ventricular myectomy in children with HCM in the United Kingdom. Data from the NCHDA data set will be linked with hospital admission and mortality data to provide information on longer term outcomes following surgery. The data from this study will be used to inform national service development and provision for this patient group with the aim of improving patient outcomes and care.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
25/EM/0008
Date of REC Opinion
21 Jan 2025
REC opinion
Favourable Opinion