Mutational analysis of testicular serous tumours
Research type
Research Study
Full title
Mutational analysis of the MAP kinase pathway in testicular serous tumours
IRAS ID
161382
Contact name
Zsombor Melegh
Contact email
Duration of Study in the UK
0 years, 2 months, 1 days
Research summary
Serous neoplasms of the testis are rare lesions and range from serous borderline tumour to serous carcinomas. The origin of these tumours is uncertain. The mitogen-activated protein kinase (MAPK) signalling pathway is involved in the growth and differentiation of tissues. Mutations affecting a component of this pathway are seen in > 50% of serous borderline tumours and low grade serous carcinomas of the ovary. Mutational analysis of the MAPK signalling pathway in testicular serous tumours would provide a useful link between ovarian and serous tumours and shed further light on the origin of these tumours. For the mutational analysis paraffin embedded archived tumour samples would used from patients with histological diagnosis of serous testicular tumours. The genetic analysis would be performed at the Bristol Genetics Laboratory.
REC name
London - South East Research Ethics Committee
REC reference
15/LO/0717
Date of REC Opinion
16 Apr 2015
REC opinion
Favourable Opinion