MUSHD
Research type
Research Study
Full title
MUscle Stunning in Haemodialysis
IRAS ID
244334
Contact name
Nick Selby
Contact email
Sponsor organisation
University of Nottingham
ISRCTN Number
ISRCTN00000000
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
00000, N/A
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Skeletal muscle (muscles attached to bones) weakening and loss of mass is very common in patients who receive haemodialysis treatment (a method by which waste products and extra fluid are removed from blood when kidneys fail to do their job), which makes them subject to complications, poor quality of life, frailty and early death. Certain exercises have shown effective results on this muscle weakening condition, but exercise is not always easily accessible or done by the typically old and frail population. Therefore, there is a demand for a new treatment strategy. To help achieve this, we need to understand the reasons behind muscle weakening and mass loss. Multiple reasons have been suggested in previous studies, one of which suggested that the haemodialysis procedure itself may be responsible for muscle weakening because it leads to decrease blood supply to heart and brain tissues. Up to date, it is not known if similar effect could be the reason behind skeletal muscle weakening. This study will be done to test if haemodialysis leads to changes in skeletal muscle tiny vasculature flow within single treatment session. It will be done on adult patients who have been receiving haemodialysis at Royal Derby Hospital for more than 3 months. It will take place within single haemodialysis sessions. The study will last for 4 hours in addition to 30 minutes before the dialysis. Finding of this study could help in adjusting current haemodialysis procedure and prevent muscle weakening for improved patients’ quality of life. Finally, the study is sponsored by The University of Nottingham.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
18/EM/0186
Date of REC Opinion
10 Jul 2018
REC opinion
Unfavourable Opinion