Muscular Assessed Knee Replacement Outcome (MAKRO)
Research type
Research Study
Full title
Intrinsic muscular physiological factors contributing to early outcome status after primary total knee replacement.
IRAS ID
218322
Contact name
Kimberley Moore Ede
Contact email
Sponsor organisation
University of Edinburgh
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 0 months, 30 days
Research summary
MAKRO is a longitudinal prospective cohort study. It will research how the health of patients' upper leg muscles at time of surgery influence to their early outcomes assessments following primary knee replacement.
Quadriceps muscle biopsies from patients undergoing primary knee replacement will undergo laboratory analysis. The patients will be followed up at outpatient clinics for 12 months. Assessments will include Patient Reported Outcomes Measures and Functional Assessments to evaluate their physical performance.
The laboratory analysis will identify the health and state of the muscle cells and muscle precursor stem cells. Previous pilot work in our department has indicated that this may be a predictive factor of early outcomes.
There will also be a comparison of how lifestyle factors affect the muscle health and ability to recover.
Identification and clarification of these factors may lead to better patient management and optimisation of primary knee replacement outcomes in the future.
REC name
South East Scotland REC 01
REC reference
17/SS/0088
Date of REC Opinion
7 Aug 2017
REC opinion
Further Information Favourable Opinion