Muscle Physiology& Function in Crohn’s and Non-Alcoholic Liver Disease
Research type
Research Study
Full title
SKELETAL MUSCLE METABOLISM AND FUNCTION IN INFLAMMATORY DISEASE: A PILOT STUDY IN CROHN’S DISEASE AND NON-ALCOHOLIC FATTY-LIVER DISEASE WITH COMPENSATED CIRRHOSIS
IRAS ID
179602
Contact name
Gordon Moran
Contact email
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Crohn's Disease (CD) and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases where commonly, sufferers are unable to get enough nutrition from the food they eat. In CD, up to 75% of hospitalized patients are malnourished, when it comes to paediatric CD, 60% of newly-diagnosed children have weight loss,with decreased growth and malnutrition showing several years after diagnosis in 15% of children.This is seen as loss of muscle, causing a constant feeling of tiredness and fatigue.
NAFLD affects children, adolescents and adults alike. Sufferers also have problems in being able to get the right amount of nutrients from the food they eat which can lead to muscle loss.
Both Patients with CD and NAFLD experience loss of muscle mass which has a negative effect on physical activity and patient well-being. It is not yet clear how much of an affect CD and NAFLD disease, diet and physical activity have on muscle function. In this study we plan to measure the effects of food intake and a programme of exercise on muscle and its function in CD and NAFLD and compare this with Healthy Volunteer Controls.We will recruit participants to each of the following groups:
• Patients with active Crohn’s disease
• Patients with Crohn’s disease in remission
• Patients with NAFLD
• Patients with NAFLD compensated cirrhosis
• Age, BMI and gender matched healthy volunteersREC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
15/WM/0285
Date of REC Opinion
30 Sep 2015
REC opinion
Further Information Favourable Opinion