MULTIVARIATE ANALYSIS OF PATIENTS WITH OCCUPATIONAL ASTHMA
Research type
Research Study
Full title
MULTIVARIATE ANALYSIS OF PATIENTS WITH OCCUPATIONAL ASTHMA
IRAS ID
209627
Contact name
Paul Cullinan
Contact email
Sponsor organisation
Nouvel Hopital Civil
Duration of Study in the UK
0 years, 9 months, 31 days
Research summary
Occupational asthma (OA) is a substantial public health issue as the cause of about 15% of cases of adult-onset asthma, with important social and employment consequences. The outcome of OA is variable, with some - but not all - patients having remission of their disease after avoidance of further exposure to the causal agent. Analyses of patients with non-occupational asthma have revealed distinct subgroups (phenotypes) with different outcomes and variable requirements for different treatments. Such subgroups have not been studied in detail in a large population with OA.
Aims: The main aim of this study is to phenotype patients with OA arising from a variety of occupational agents using the wide range of clinical, functional and inflammatory characteristics that have been collected during their routine investigation and care.
Secondary aims: To perform further hypothesis-driven comparisons between different subsets of subjects (e.g. different categories of causal agents) based on inferences from previous literature.
Data collection: The study is an international, multicentre, observational retrospective study. It will include all consecutive patients who showed a positive response following exposure to the causal agent (Specific Inhalation Challenge) from January 2006 to December 2015. Twenty-eight European centres and one centre in each of Canada and South Korea will supply anonymous data in a spreadsheet format for analysis.
The following information will be included from records previously collected: age and sex, occupational data and workplace exposures, clinical characteristics, work related asthma symptoms, data on associated disorders, diagnostic procedures, treatment, severity and control of asthma, baseline functional parameters, results of Specific Inhalation Challenge, markers of airway inflammation, any adverse events during Specific Inhalation Challenge and socio-economic outcome at the time of the challenge.REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
17/NE/0144
Date of REC Opinion
26 Apr 2017
REC opinion
Favourable Opinion