Multiple Breath Washout, a clinimetrics dataset

  • Research type

    Research Study

  • Full title

    Multiple Breath Washout in paediatric chronic airways disease: Building a clinimetrics dataset



  • Contact name

    Jane C Davies

  • Contact email

  • Sponsor organisation

    Imperial College London

  • Duration of Study in the UK

    5 years, 0 months, 2 days

  • Research summary

    The Multiple breath washout (MBW) test has been established for more than 60 years, but it is not used as frequently used as spirometry, the gold standard of lung function testing. Lung clearance index (LCI) is a result gained from MBW that tells us how clear someone's airways are. With the improvement of care, many patients now have normal spirometry and so more sensitive markers/outcome measures of disease severity are required to continue to monitor disease and prevent further disease deterioration. Whilst MBW is established as a tool many discrepancies and unknowns still exist, limiting its standardised widespread use. These factors are, differences in equipment, what normal variation and repeatability are, who will benefit the most from utilisation of this test and how well LCI relates to other measures of respiratory disease. This study aims to address these questions.

  • REC name


  • REC reference


  • Date of REC Opinion

    28 Feb 2017

  • REC opinion

    Favourable Opinion

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