Multimorbidity and Cardiovascular Risk Factors after Renal Transplant
Research type
Research Study
Full title
Multimorbidity and cardiovascular risk factors after renal transplant
IRAS ID
354911
Contact name
Nicholas Selby
Contact email
Sponsor organisation
University Hospitals of Derby and Burton
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
A pilot study to understand the development of cardiovascular risk factors and multimorbidity in renal transplant patients after transplant.We aim to understand the baseline characteristics of cardiovascular risk factors in the patient population as they return from transplant surgery to their referring centre, and then how these develop in the first year. The results of the study would aim to contribute to an evidence base regarding cardiovascular risk factors and identify targets for intervention within the first year. Early identification of modifiable risk factors can contribute to improvement of cardiovascular outcomes and graft survival.
We aim to understand how patients develop multiple health conditions after a kidney transplant. Having multiple medical problems increases the risk of hospital admission and death, and correlates with worse quality of life. Understanding how this happens will help us develop services to help patients with multiple health conditions.
We plan to recruit patients as they return to have their care at the study hospital after kidney transplant in our local transplant centre. We plan to assess at baseline their comorbidities, cardiovascular risk factors, demographics, functional status, and biochemical markers.
We plan to use bioimpedance machines to assess the change in body composition (fluid, muscles, fat) over the one-year period post-transplant.
We then plan to assess them again at 3 months, 6 months and 1 year to understand how these things change over this timeframe.
We plan to do questionnaires to assess the impact physical health is having on patients.
We plan also to do a subset of structured interviews at the end of the study to understand barriers to improved cardiovascular health and impact of multimorbidity.REC name
London - South East Research Ethics Committee
REC reference
25/PR/0987
Date of REC Opinion
14 Aug 2025
REC opinion
Further Information Favourable Opinion