Multicenter Aggression subTyping Research in Conduct Syndromes
Research type
Research Study
Full title
Multicenter Aggression subTyping Research in Conduct Syndromes (MATRICS)
IRAS ID
164728
Contact name
Michael Craig
Contact email
Duration of Study in the UK
3 years, 10 months, 13 days
Research summary
Children and adolescents with oppositional defiant disorder (ODD) or conduct disorder (CD) show a repetitive and persistent pattern of aggressive behaviour. One can distinguish between different forms of aggression, such as uncontrolled, emotional, “impulsive aggression” and planned, goal-directed “instrumental aggression”. Another distinction is based on the presence of callous-unemotional (CU) traits, defined as a lack of prosocial emotions. These subtypes may be mediated by unique underlying mechanisms. More knowledge is needed about the behavioural, cognitive, neural and (neuro)biological as well as genetic bases of aggression in childhood- and adolescent-onset CD and/or ODD.
The main objectives of this study are to (I) investigate characteristics of children and adolescents with CD and/or ODD in comparison with typically developing (TD) controls and (II) examine subtypes of CD and/or ODD on the behavioural, cognitive, neural, (neuro)biological and genetic level.
REC name
London - Westminster Research Ethics Committee
REC reference
15/LO/0694
Date of REC Opinion
6 May 2015
REC opinion
Unfavourable Opinion