Multi-parameter analysis of platelet function
Research type
Research Study
Full title
Multi-parameter analysis of platelet function: the impact of cardiometabolic disease
IRAS ID
285583
Contact name
Jonathan Gibbins
Contact email
Sponsor organisation
University of Reading
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Small blood cells called platelets help blood to clot when we injure ourselves, but sometimes they form dangerous clots inside blood vessels that can cause heart attacks. People may be prescribed anti-platelet drugs that help to stop platelets from forming dangerous clots, but they do not work for everybody. Researchers funded by the British Heart Foundation at the University of Reading have found that the way people’s platelets work varies, and these differences might make certain anti-platelet drugs more or less effective for some people. These differences might be particularly important for people with Type II Diabetes, who are at increased risk of heart attacks and other forms of cardiovascular disease. To understand if anti-platelet treatment can be safer and more effective, we need to recruit diabetic and non-diabetic patients with or without ischemic heart disease willing to donate small blood samples. We will use these samples to identify differences in the way platelets work in diabetic and non-diabetic patients and test the effectiveness of antiplatelet drugs in a lab. This information will help researchers and clinicians understand why heart disease is more common in diabetic patients, assist in the development of new treatments and guide the use of existing antiplatelet drugs to maximise their safety and effectiveness for individual patients.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
20/NW/0364
Date of REC Opinion
23 Sep 2020
REC opinion
Further Information Favourable Opinion