Mucosal Molecular Mechanisms in Allergic Rhinitis(M3AR)

• Research type

  Research Study

• Full title

  Mucosal Molecular Mechanisms of Allergic Rhinitis (M3AR): Assessment of mediators after nasal allergen challenge with grass pollen

• IRAS ID

  238957

• Contact name

  Trevor Hansel

• Contact email

  t.hansel@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Clinicaltrials.gov Identifier

  17/SC/0680, REC reference

• Duration of Study in the UK

  0 years, 4 months, 31 days

• Research summary

  The overall aim of the study is to characterise the molecular basis of the nasal immune response after spraying the nose with grass pollen (allergen). In particular, we would like to describe the kinetics of four immune mediators after a nasal allergen challenge. This will be measured in a series of samples collected from absorbing the nasal mucosal lining fluid and pinhead of nasal tissue from healthy adult volunteers and those with summer symptoms of hay fever (allergic rhinitis). This will help us to further our understanding of how the human nose responds to allergen and which nasal cells and molecules take part in the allergic reaction.

• REC name

  South Central - Hampshire A Research Ethics Committee

• REC reference

  17/SC/0680

• Date of REC Opinion

  26 Jan 2018

• REC opinion

  Further Information Favourable Opinion