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MSIPC-2

  • Research type

    Research Study

  • Full title

    Role of Remote Ischaemic Preconditioning on Activity, Fatigue and Gait of people with Multiple Sclerosis.

  • IRAS ID

    262744

  • Contact name

    KPS Nair

  • Contact email

    siva.nair@sth.nhs.uk

  • Sponsor organisation

    Sheffield Teaching Hospitals

  • Duration of Study in the UK

    1 years, 11 months, 30 days

  • Research summary

    Regular physical activity has been shown to improve physical fitness, fatigue, quality of life, and reduce the progression of disability in people with multiple sclerosis (MS). However, people with MS are less physically active than the general population, due to both psychological factors such as lack of motivation, self-belief and self-regulatory constructs, and physical factors such as fatigue, weakness, pain and ataxia.\n\nRemote Ischemic Pre Conditioning (RIPC), the inflation of a blood pressure cuff around the arm to temporarily occlude blood circulation, has been shown to improve exercise performance and delay fatigue in athletes. RIPC is a simple and easy intervention which could have a significant impact on physical activity of people with MS. However, there is little to no research examining the effect of RIPC on walking or exercise performance in MS patients. Preliminary studies of ours showed that RIPC is safe and well tolerated by MS patients, and suggested an improvement in distance walked during the 6 minute walk test (6MW), a reduction in perceived exertion after exercise and improved exercise tolerance in MS patients. The aim of this trial is to assess whether RIPC can improve activity, gait and reduce fatigue in people with MS. \n\nParticipants will attend four study visits. They will be randomised to receive either RIPC or a dummy intervention (sham) which they (or their carer) will be taught how to perform and be asked to do so at home every day for six weeks. \n\nPhysical activity, gait and fatigue will be compared before and after the intervention period. Participants will be asked to wear an activity monitor at home for 1 week before and after the intervention to measure levels of activity. To assess gait, participants will complete the 6 minute walk test wearing inertial sensors which measure gait and distance walked. The modified fatigue impact scale will be completed before and after the intervention and levels of exertion recorded after each 6 minute walk test. \n\n

  • REC name

    Yorkshire & The Humber - Bradford Leeds Research Ethics Committee

  • REC reference

    19/YH/0187

  • Date of REC Opinion

    3 Jun 2019

  • REC opinion

    Favourable Opinion