MSCs in fracture healing
Research type
Research Study
Full title
Mesenchymal stem cells in fracture healing
IRAS ID
235753
Contact name
Peter Giannoudis
Contact email
Sponsor organisation
Faculty of medicine and health, the University of Leeds
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
The overarching purpose of this study is to understand how mesenchymal stem cells (MSCs) participate in normal bone physiology and how they influence fracture repair in healthy individuals, as well as in patients with musculoskeletal pathologies. In many cases poor bone healing is attributed to either the lack/low numbers of these MSCs at the site of repair, or to the deficiencies in their interactions with other cells or growth factors in the neighbouring microenvironment. To address these important, clinically relevant issues, we plan to conduct a five year study of MSCs in patients admitted to the Trauma Orthopaedics department, Leeds General Infirmary. Patients will be invited to participate and donate a small amount of tissue (including bone, periosteum and connective tissue), which would otherwise be discarded as part of their surgical procedure. Patients will also be asked to donate small volumes of blood and bone marrow. For comparrison of factors in the blood control blood samples will be recruited from the family members of patients as well as outside of the clinical setting.
Investigative work will be carried out by or under the supervision of researchers at the Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds.REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
18/YH/0166
Date of REC Opinion
10 Oct 2018
REC opinion
Further Information Favourable Opinion