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MROC: MR in Ovarian Cancer

  • Research type

    Research Study

  • Full title

    The Impact of Multiparametric MRI on the Staging and Management of Patients with Suspected or Confirmed Ovarian Cancer.



  • Contact name

    Andrea Rockall

  • Contact email

  • Duration of Study in the UK

    4 years, 0 months, 31 days

  • Research summary

    In patients with suspected Ovarian Cancer (OC), current guidelines recommend that a CT scan is performed in order to inform decisions as to what stage the cancer is at, and if the patient should have up-front surgery. Recent developments in MRI imaging have led to a new MRI technique called multiparametric MRI (mpMRI), which has the potential to provide additional information that may influence decisions about how the patient should be treated.\n\nThe aim of this study is to compare the staging of cancer and treatment plans for patients with suspected or confirmed OC, based upon findings from a CT alone, an mpMRI alone or a combination of CT and mpMRI. \n\n645 women with suspected or confirmed OC will be recruited onto the study and will undergo an mpMRI in addition to the standard of care CT. The MDT (the medical team who make decisions about a patients care) will then determine the stage and treatment plan for the patient based upon the CT alone. Any critical findings from the mpMRI will be revealed to the MDT after they have made an initial decision; the patient will then progress with treatment, as decided. A series of theoretical staging decisions and treatment plans will also be produced by the local team and two external MDTs. 6 months after entry onto the study, the local MDT will conduct a final case review. All available information will be reviewed and the correct stage and treatment plan for that particular patient will be determined. \n\nDuring the study, patients will only attend one extra appointment for the mpMRI, all other data will be provided by their medical records and the MDTs. Participating patients will also be given the option to donate tissue samples, which would be obtained during surgery.\n

  • REC name

    London - Bromley Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    24 Nov 2015

  • REC opinion

    Favourable Opinion