MRI of transplanted lung function
Research type
Research Study
Full title
Using MRI scans to measure how well transplanted lungs are working
IRAS ID
309493
Contact name
Andrew Fisher
Contact email
Sponsor organisation
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
In this study we will use advanced magnetic resonance imaging (MRI) methods to visualise and quantify lung ventilation properties in patients who have received a lung transplant. We will compare two patients cohorts: patients with and without chronic lung rejection (also called chronic lung allograft dysfunction). The study purpose is to characterise the difference in regional lung ventilation properties between these two groups. The primary measurement is a relatively new approach to ventilation imaging, where an inert MRI-visible gas (perfluoropropane) is inhaled and imaged in the lungs to report on lung ventilation properties, identifying areas of normal lung ventilation, reduced ventilation and/or areas of air trapping (ie. areas where the air does not leave the lung as normal).
If successful, our study will demonstrate the ability of lung MRI methods to report on changes in regional lung ventilation associated with lung allograft dysfunction, providing a safely repeatable alternative to existing clinical ventilation imaging assessments that rely on radioisotopes or ionising radiation. With this approach, we hope to be able to detect patients with early signs of chronic lung allograft dysfunction.REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
22/EM/0075
Date of REC Opinion
31 Mar 2022
REC opinion
Favourable Opinion