MRI of the fetal lungs
Research type
Research Study
Full title
Consecutive fetal MRI in cases of Congenital diaphragmatic hernia.
IRAS ID
183684
Contact name
Elspeth Whitby
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 11 months, 1 days
Research summary
We have noticed from follow up of babies who have had 2 magnetic resonance imaging (MRI) scans before they were born (fetal MRI, when mum was pregnant) for a condition called congenital diaphragmatic hernia (CDH) that in the cases where 2 scans have been performed and there has been a reduction in the lung size that although these babies are well enough to undergo surgery after birth but that they have died unexpectedly within a few days of seemingly successful surgery.
This is a pilot project that will include a fetal MRI scan all cases of CDH at the time of diagnosis (usually within a few days of the ultrasound scan performed at 20 weeks of pregnancy) as part of standard clinical care and a second fetal MRI scan in the pregnancies that continue (this will be a research scan and extra to what is offered as part of clinical care). The imaged obtained will be used to gain information on lung size.The babies notes will be reviewed after birth to find out how they are, what surgery was performed and what was found at surgery. We will use this information to see if it suggests that any change specific changes in lung size can predict how the babies will do.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
15/YH/0540
Date of REC Opinion
28 Jan 2016
REC opinion
Further Information Favourable Opinion