MRI-MVR (pilot)
Research type
Research Study
Full title
Serial change in cardiac reverse remodelling, functional capacity and quality of life following surgical and transcatheter mitral valve repair or replacement for mitral valve disease (pilot study)
IRAS ID
184499
Contact name
Stephen Wheatcroft
Contact email
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Mitral regurgitation (MR) is an abnormal back flow of blood from the left ventricle into the left atrium during each heart beat. It occurs because the leaflets of the mitral valve do not meet to make a tight seal and therefore the valve leaks. Mitral regurgitation imposes an extra strain on the heart so that it has to work much harder to supply the body with the required amount of blood. The abnormal backflow of blood also causes pressure to build up in the lungs. Severe MR can cause heart failure and ultimately death.
MR is treated with surgery, by either replacing or repairing the mitral valve. More recently new techniques for replacing the valve percutaneously (without the need for open heart surgery) have been developed. Surgical valve repair is currently recommended over replacement and percutaneous treatments, however, the guidelines suggesting this use historic evidence, which compared outdated techniques for mitral valve replacement. The main aim of this study is to establish whether there is a difference in outcomes (in terms of cardiac remodelling, exercise capacity and quality of life measures) following mitral valve repair, replacement and percutaneous intervention.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
15/YH/0503
Date of REC Opinion
24 Dec 2015
REC opinion
Further Information Favourable Opinion