MRI for Aortic Dissection to Visualise inflammation V.1
Research type
Research Study
Full title
Magnetic Resonance Imaging (MRI) for Aortic Dissection to Visualise Inflammation
IRAS ID
239240
Contact name
Andrea Salzano
Contact email
Sponsor organisation
University of Leicester, Research & Enterprise Division, Research Governance Office
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Aortic Dissection (AD) is a condition characterised by a disruption of the different layers of the aortic wall, determining a false lumen and impairment in organ perfusion. Despite the underlying mechanism of the condition remain unclear, growing evidence suggests that inflammation of the aorta, triggered by macrophage infiltration, could have a pivotal role in the disease development. Animal models have demonstrated that Macrophage infiltration could be feasible by contrast-enhanced Magnetic Risonance Imaging (MRI), using ultra small super para magnetic iron oxides (USPIOs). Aim of the present study is to investigate the hypothesis that macrophage-mediated inflammation can be visualised in the aorta of patients with AD using the USPIO-enhanced MRI technique. This information is important because can lead to improve the understanding of the AD pathophysiology , and may allow for a potential development of treatments aimed at macrophage-mediated processes.
REC name
London - Surrey Research Ethics Committee
REC reference
19/LO/0384
Date of REC Opinion
26 Apr 2019
REC opinion
Further Information Favourable Opinion