MRI assessment of CRC hypoxia (MATCH).
Research type
Research Study
Full title
MRI assessment of hypoxia and perfusion in primary colorectal cancer. The MATCH study.
IRAS ID
121610
Contact name
Vicky Goh
Contact email
Sponsor organisation
King’s College London
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
A single centre, non-randomised prospective exploratory imaging study.
Its primary objective is to investigate the ability of a relatively novel MRI sequence (BOLD MRI) to depict the presence of hypoxia in primary colorectal cancer.
Secondarily, it aims to correlate BOLD MRI with another MRI sequence, dynamic contrast enhanced MRI (DCE MRI), and with a PET scan specifically targeted at hypoxia, 18F-MISO PET.
Hypoxia is a condition arising in living tissue when the oxygen supply does not adequately cover the cellular metabolic demands. The presence of areas of hypoxia is very common in solid tumours and is considered a leading cause of resistance to both radiotherapy and chemotherapy treatments; it is also indicative of a more aggressive tumour type with poorer therapeutic response and prognosis.
Clinical measurement of hypoxia in vivo is unsatisfactory at present: none of the available techniques has become established in routine clinical practice, either because they rely on invasive electrode measurements or because they are not available to most NHS radiology departments.
The ability to identify regional hypoxia using standard imaging modalities, such as MRI, is an attractive proposition: these methods may help identify patients who would benefit from a higher radiotherapy dose (or tailored to hypoxic regions) or from the administration of specific hypoxia-modifying chemotherapy drugs.
Up to 34 patients with primary colorectal cancer, undergoing standard staging imaging at Guy’s & St Thomas NHS Trust and deemed suitable for surgical resection, will be recruited. They will be invited to undergo a combined PET/MRI study, consisting of an MRI examination of their abdomen/pelvis (including BOLD and DCE sequences) and one 18F-MISO PET scan, before their operation.
Measurements derived from the MRI scan will be correlated with measurements derived from the 18F-MISO PET and from histopathological analysis of the surgical resection specimen, including immunohistochemistry.REC name
London - Westminster Research Ethics Committee
REC reference
15/LO/0191
Date of REC Opinion
23 Mar 2015
REC opinion
Further Information Favourable Opinion