MRI and gait in dHMN
Research type
Research Study
Full title
Exploring muscle structure, function and gait patterns in people with Distal Hereditary Motor Neuropathy: natural history and the effect of rehabilitation interventions.
IRAS ID
270708
Contact name
Gita Ramdharry
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
Z6364106/2019/10/153, UCL Data Protection Registration number ; NCT04193228, Clinicaltrials.gov
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Walking impairments are common in people who have a particular type of nerve condition Distal Hereditary Motor Neuropathy (dHMN) than in people without the condition. dHMN is a condition which affects the nerves that move the muscles of the arms and legs, causing a variety of symptoms including muscle weakness. Most often the impairments are most evident in the feet and legs.
The study will seek to explore how people with dHMN walk and how physical therapies can help. We aim to investigate this through a series of clinical examinations and rehabilitation treatments, such as ankle braces and exercises. The study will involve three measurement sessions (0 months, 12 months, and 16 months), and a 4-month therapeutic exercise program for their legs. During measurement session;
First: We will be analysing participants walking, using specialist movement analysis equipment. We will do this in a few conditions: 1) wearing simple shoes, 2) wearing prescribed ankle brace (where appropriate), and 3) wearing carbon fibre AFO’s.
Second: we will be measuring legs muscle strength using a specialist measuring device.
Third: we will be taking images of the muscles of legs using MRI scans.
After the second measurement session, participants will be given instructions in the exercise training protocol. The measurement session will take place at the Centre for Neuromuscular Diseases (CNMD) in the National Hospital for Neurology and Neurosurgery (NHNN).REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
20/LO/0519
Date of REC Opinion
22 Jul 2020
REC opinion
Further Information Favourable Opinion