MP-USS versus MP-MRI for prostate cancer diagnosis

• Research type

  Research Study

• Full title

  A prospective multi-centre cohort diagnostic utility study with built-in randomisation of order of biopsies to compare index test diagnostic strategies of multi-parametric ultrasound (mp-USS) to multi-parametric MRI (mp-MRI) in men for the diagnosis of clinically significant prostate cancer.

• IRAS ID

  173242

• Contact name

  Hashim Ahmed

• Contact email

  hashim.ahmed@nhs.net

• Duration of Study in the UK

  1 years, 11 months, 30 days

• Research summary

  We wish to compare a diagnostic strategy for prostate cancer using newer types of ultrasound scanning with the existing one using magnetic resonance imaging (MRI). We will look at men who have already had one prostate biopsy and are referred for risk stratification. At present MRI scanning is used to identify areas of the prostate which may contain cancer and would warrant further investigation with biopsy. MRI however is a relatively expensive test and is not suitable for all men such as those with metal implants, poor kidney function and claustrophobia.
  If ultrasound scanning, which is perhaps half the cost of MRI, could be substituted the economic gains might be considerable. Ultrasound could also be performed in the outpatient setting by the Urologist, removing a visit to hospital and the potential for delay from a patients journey.
  The study will be conducted at University College Hospital . There may also be participation by two satellite centres in Taunton and Coventry. We intend to recruit men over two years. They will all undergo a multiparametric MRI scan (the normal diagnostic pathway) as well as a multiparametric ultrasound scan in two outpatient visits. Any abnormalities on these two scans considered suspicious for cancer will be biopsied under local anaesthetic and optional sedation. The biopsy results for abnormalities detected by ultrasound will be compared with the biopsy results for those abnormalities seen on MRI in order to answer our primary research question.

• REC name

  London - Brent Research Ethics Committee

• REC reference

  15/LO/1331

• Date of REC Opinion

  8 Oct 2015

• REC opinion

  Further Information Favourable Opinion