Monitoring Thrombus Stability Over Time Using SWE
Research type
Research Study
Full title
Improving clinical practice for patients with a blood clot: A exploratory study to investigate the ability of Shear Wave Elastography technology to determine the stability of thrombus over time in patients presenting with an acute deep vein thrombosis
IRAS ID
235095
Contact name
Helena Edlin
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 5 days
Research summary
In summary, the study will be carried out over a 24-month period on patients with an acute leg deep vein thrombosis (blood clot). The study will investigate if with the addition of an ultrasound technique known as Shear Wave Elastography to a vascular Duplex ultrasound scan, it is possible to determine the stability of the thrombus by measuring its elasticity. Stability of the thrombus will be defined when there is no change in SWE measurements and they remain stable. The study will record the elasticity of each thrombus at the point of diagnosis and monitor the changes in the thrombi's stiffness over time. The data will be collected in order to provide information which will hopefully help inform further studies to provide data which will help to clinically manage these patients by determining the best treatment pathway for them and the potential to create more individualised treatment.
This project will be conducted in accordance with the study protocol and the ethical principles outlined by Good Clinical Practice (GCP) and the Declaration of Helsinki in its most current version.REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
22/LO/0530
Date of REC Opinion
16 Aug 2022
REC opinion
Favourable Opinion