MONITOR-NIV
Research type
Research Study
Full title
Monitoring respiratory muscle function in acute respiratory failure patients requiring non-invasive respiratory support (MONITOR-NIV): A prospective observational study
IRAS ID
342581
Contact name
Zudin Puthucheary
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
1 years, 2 months, 31 days
Research summary
Acute respiratory failure, is a life-threatening condition where patients need help to breathe because their lungs cannot take-up enough oxygen. This affects more than 600,000 patients admitted to NHS hospitals each year, and the majority of them will need supplemental pressurised oxygen via wide nasal cannulae and a tight-fitting mask (technically called high-flow, CPAP or BiPAP). However, effective use of these respiratory support treatments relies on rigorous respiratory function monitoring and good clinical decisions. Two independent national reports (i.e. NCEPOD and HSIB) have highlighted important problems of how these treatments are used in hospitals, leading to worse outcomes for patients. International studies show that treatment failure affects three out of five patients who require invasive ventilation under general anaesthesia, potentially leading to physical and mental long-term sequelae.
This study aims to understand respiratory muscle function in patients with acute respiratory failure requiring non-invasive respiratory support. The main aims are:
1- to investigate the usability of advanced respiratory muscle monitoring using ultrasound (US) and electrical impedance tomography (EIT) in guiding clinical decision-making for acute respiratory failure patients on non-invasive respiratory support.
2- To evaluate the feasibility of respiratory muscle US and EIT in the clinical setting for acute respiratory failure patients on non-invasive respiratory support
3- To measure the changes in the patient's respiratory muscular function
4- To compare the changes in the patient's respiratory muscular function with the changes in treatment settings
5- To evaluate the incidence and association with treatment failure (i.e. composite outcome intubation and/or death).REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
25/YH/0264
Date of REC Opinion
9 Jan 2026
REC opinion
Further Information Favourable Opinion