• Research type

    Research Study

  • Full title

    Monitoring Tuberculosis Treatment



  • Contact name

    Mahdad Noursadeghi

  • Contact email

  • Sponsor organisation

    Joint Research Office

  • Identifier

    Z6364106/2020/04/08 , Finance Data Protection

  • Duration of Study in the UK

    4 years, 11 months, 30 days

  • Research summary

    Novel approaches to monitor the responses to treatment of tuberculosis (TB) are needed to support infection control decisions, evaluate treatment efficacy and guide duration of antimicrobial therapy. This study aims to evaluate the application of a new sputum test. called the mycobacterial bacterial load (MBL) assay based on detection of the RNA of Mycobacterium tuberculosis (Mtb), and a new blood test for human blood RNA signatures of active TB, for monitoring the response to TB treatment.

    The study involves obtaining sputum and blood samples with a diagnosis of TB, at the same time as other routine tests, before starting treatment and at selected time points after starting treatment in order to evaluate how well the new tests predict the response to treatment.

    The results of this research study will help us in the future to confirm that we are giving the correct treatment, confirm when patient with TB is no longer infectious to other people, and confirm when they have been fully cured of the infection.

  • REC name

    London - Stanmore Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    17 Nov 2020

  • REC opinion

    Favourable Opinion

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