Molecularly Imprinted Polymers (MIPs) in Leukaemia Diagnosis
Research type
Research Study
Full title
Developing a sensitive and specific diagnostic biosensor using Molecularly Imprinted Polymer (MIP) recognition ligands to lineage specific cell surface antigens for leukaemia diagnosis
IRAS ID
251011
Contact name
Muttuswamy Sivakumaran
Contact email
Sponsor organisation
North West Anglia NHS Foundation Trust
Clinicaltrials.gov Identifier
not applicable, not applicable
Duration of Study in the UK
0 years, 1 months, 30 days
Research summary
This is a project to develop molecularly imprinted polymers (MIPs), the so-called 'plastic antibodies' to detect antigens on leukaemic cells to aid diagnosis of leukaemias. At present antibodies against various antigens present on leukaemic cells are used in the diagnosis of leukaemias. Although the use of antibodies for leukaemia diagnosis is well established, they have drawbacks- they are expensive, short shelf life and require refrigeration. These requirements restrict their use in developing/poor countries. MIPs on the other hand are cheaper to manufacture and are robust at room temperature for very long period of time (years). Furthermore, MIPs could be incorporated into a variety of sensor platforms to develop point of care devices.
REC name
West of Scotland REC 3
REC reference
18/WS/0177
Date of REC Opinion
14 Sep 2018
REC opinion
Favourable Opinion