Molecular Mechanisms regulating Smooth Muscle Cell Proliferation
Research type
Research Study
Full title
Molecular Mechanisms regulating Smooth Muscle Cell Proliferation
IRAS ID
250825
Contact name
Mark Bond
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Coronary artery bypass grafting (CABG) is one of the main treatment for patients suffering from coronary heart disease. This involves removal of part of the saphenous vein from the patients leg, which is then used to bypass the blocked coronary artery. Unfortunately, many of these grafts fail within ten years. This is due to the surgical manipulation and the change from low venous pressure to high arterial pressure. This 'injury' stimulates growth and migration of cells that live in the vessel wall. This increased growth and migration ultimately blocks the graft. Our research will study the mechanisms controlling the growth and migration of these cells, with the aim of identifying new therapies to limit vein graft failure.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
20/NE/0103
Date of REC Opinion
10 Jun 2020
REC opinion
Further Information Favourable Opinion