Molecular mechanisms regulating cardiac fibroblast behaviour

• Research type

  Research Study

• Full title

  Molecular Mechanisms regulating cardiac fibroblast proliferation

• IRAS ID

  282301

• Contact name

  Mark Bond

• Contact email

  mark.bond@bris.ac.uk

• Sponsor organisation

  University of Bristol

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  Cardiac fibrosis is the main pathophysiological processes contributing to heart failure. Excessive ECM production and increased proliferation of cardiac fibroblasts contributes towards cardiac fibrosis, which increases myocardium stiffness, causing systolic/diastolic cardiac dysfunction and ultimately heart failure. Unfortunately, current treatment options are only partially effective. Hence a better understanding of the underlying mechanisms is required to help develop novel therapies. Our research will study the mechanisms controlling the growth and migration of cardiac fibroblasts, with the aim of identifying new therapies to reduce cardiac fibrosis.

• REC name

  South West - Frenchay Research Ethics Committee

• REC reference

  22/SW/0128

• Date of REC Opinion

  15 Sep 2022

• REC opinion

  Favourable Opinion