Molecular markers and vasculature in in-transit melanoma - Version 1.

• Research type

  Research Study

• Full title

  Molecular markers and vasculature in in-transit melanoma

• IRAS ID

  276259

• Contact name

  Anthony Maraveyas

• Contact email

  anthony.maraveyas@hey.nhs.uk

• Sponsor organisation

  University of Hull

• Duration of Study in the UK

  1 years, 6 months, 0 days

• Research summary

  Satellites and in-transit melanoma are cutaneous and subcutaneous lymphatic deposits of melanoma cells. Cells are discovered within regional dermal or subdermal lymphatic vessels prior to reaching the lymph node. There is little known on how lymphatics contribute to this disease. Our aim is to study archived tissues and investigate molecular drivers and at the same time investigate the surrounding vessels such as lymphatics, characterizing them in the disease state.

  Objective 1:
  To study the expression of a specific protein such as calcitonin receptor-like receptor (CLR) and to compare the abundance of this protein with other melanoma markers such as BRAF600E mutational status.

  Objective 2:
  To investigate the vasculature (lymphatics and blood) in tissue samples using specific lymphatic and endothelial cell markers.

• REC name

  North West - Greater Manchester South Research Ethics Committee

• REC reference

  20/NW/0449

• Date of REC Opinion

  25 Nov 2020

• REC opinion

  Further Information Favourable Opinion