Molecular characterisation of paediatric myelodysplasia and AML
Research type
Research Study
Full title
Molecular characterisation of Paediatric Myelodysplasia and Acute Myeloid Leukemia using next generation sequencing for improved diagnostic and prognostic patient stratification.
IRAS ID
160888
Contact name
Anupama Rao
Contact email
Sponsor organisation
Great Ormond Street for Children NHS Foundation Trust
Duration of Study in the UK
1 years, 4 months, 30 days
Research summary
Paediatric myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) are rare diseases with considerable clinical and genetic variance.
Based on recently published data we have elected to conduct a pilot study on archived samples for 2 patient cohorts - paediatric MDS and AML. By analysing a large set of genes known to be involved in the induction, development, and progression of leukaemia, we will detect changes in the genetic profiles of patients in these two cohorts.
Comprehensive correlation of genetic data with each patient's clinical characteristics may identify molecular changes of potential diagnostic and prognostic relevance, and provide a basis for a model that can be used in the diagnosis and treatment of future patients.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
14/SC/1449
Date of REC Opinion
11 Dec 2014
REC opinion
Favourable Opinion