Modulation of Acute Gingival Inflammation
Research type
Research Study
Full title
Modulation of Acute Gingival Inflammation by Na-bicarbonate. An Acute Inflammatory Model.
IRAS ID
183973
Contact name
Francesco D'Aiuto
Contact email
Sponsor organisation
UCL
ISRCTN Number
ISRCTN13311671
Duration of Study in the UK
0 years, 11 months, 28 days
Research summary
The primary role of biofilm formation is well established as an etiologic factor for both caries and periodontal diseases, and the importance of effective plaque control has been stressed for many decades. However, the majority of the population appears to have difficulty in maintaining adequate standards of oral hygiene over prolonged periods of time. Clinical studies have shown a consistent plaque removal advantage for a single brushing with a baking soda dentifrice over a single brushing with dentifrices not containing this ingredient. Due to its fully reversible feature, dental plaque-induced gingivitis has been widely adopted as an experimental model to investigate the reaction of the gingival tissue to plaque accumulation. This model has been widely used since its first proposal to evaluate the efficacy of a variety of oral health product and has been slightly modified. It consists of an induction phase that occurs in 21 days and a resolution period of 14 days. The purpose of this study is to investigate the effects of Sodium bicarbonate dentifrice compared to a neutral control paste on acute and reversible changes in the gingival tissue, plaque accumulation and host response applied using an experimental gingivitis model. Additional objectives are to further understand the mechanisms of gingival inflammation.
REC name
North of Scotland Research Ethics Committee 1
REC reference
16/NS/0012
Date of REC Opinion
19 Feb 2016
REC opinion
Further Information Favourable Opinion