MODIFY
Research type
Research Study
Full title
Longitudinal Assessment of Multiple Organs in Patients with Type 2 Diabetes
IRAS ID
264182
Contact name
Dan Cuthbertson
Contact email
Sponsor organisation
Perspectum Diagnostics Ltd.
Duration of Study in the UK
5 years, 11 months, 31 days
Research summary
This will be a prospective, observational, cohort study to evaluate if imaging abdominal organs could help identify who should be prioritised to receive expensive treatments for type 2 diabetes (T2D). Participants with T2D will be recruited from three localities: Liverpool, Oxford and catchment area of Royal Free NHS Foundation Trust in London. Participants will be treated and assessed in line with normal clinical care.
Type 2 diabetes often leads to more complicated diseases. People with T2D could also develop liver disease, chronic kidney disease and cardiovascular disease. In the UK the 3.3 million people suffer from T2D, with heath care costs of £8.8 billion every year mostly as a result of disease complications. The method of diagnosing T2D is by measuring the glucose level in blood, whilst other blood and urine tests can diagnose the associated diseases in other organs. However, these tests do not provide complete information of effects on organs associated with T2D and its complications.
Metformin is the first line of treatment for Type 2 diabetes. There are patients who do not respond well to Metformin so other newer drugs needed to be prescribed for them, like Liraglutide and Semaglutide. Unfortunately, these newer drugs cost far more than Metformin, so prescribing them to everyone with type 2 diabetes is not possible for the NHS. There is a need to find a way to find more specific tests that help personalise type 2 diabetes care for the patient.
The purpose of this study is to discover whether introducing a specialist Magnetic Resonance Imaging method can aid in earlier and more accurate diagnosis of complications for T2D. This method could aid with raising the standard of care for patients, reducing number of hospital appointments, monitoring the health of other vital organs and improving overall long-term health of the patient.
REC name
London - Westminster Research Ethics Committee
REC reference
19/LO/1338
Date of REC Opinion
5 Nov 2019
REC opinion
Further Information Favourable Opinion