ModFit
Research type
Research Study
Full title
Model-driven FES therapy improves gait in people with limb loss (MoFit) -- A feasibility study for a randomised control trial
IRAS ID
354627
Contact name
Ziyun Ding
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
More than one million people every year undergo a major limb amputation worldwide. This number is predicted to double by 2050 due to the increasing prevalence of diabetes and an ageing population.
A limb amputation can lead to long-term effects. While prosthetics allow people to walk again, they do not address chronic pain. Additionally, walking with a prosthesis often results in secondary conditions. People tend to rely more on their unaffected limb, and over time, this uneven weight-bearing increases the risk of joint wear and tear in the unaffected limb, while also weakening the bone and muscle in the affected limb.
To address this issue, we have designed a novel therapy using functional electrical stimulation (FES) for this patient group. Our previous lab study shows its treatment effect in one single application. Clear evidence includes improved walking performance and positive patient feedback.
However, for patients to safely use the device in their daily walking activities, many questions remain. We need to test its longer-term effects (i.e., starting from 6 weeks) and understand patient acceptance. If they do not accept it, we need to identify the reasons. Additionally, we need to analyse different outcome measures to assess whether the design is practical, and the outcomes are relevant to the patients' lives.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
25/WM/0061
Date of REC Opinion
12 May 2025
REC opinion
Further Information Favourable Opinion