Modelling nutritional outcomes for infants with cystic fibrosis
Research type
Research Study
Full title
Modelling nutritional outcomes for infants diagnosed with cystic fibrosis by newborn screening in the West Midlands
IRAS ID
213420
Contact name
Francis Gilchrist
Contact email
Sponsor organisation
UHNM R&D Department
Duration of Study in the UK
0 years, 2 months, 1 days
Research summary
As part of a service evalation project of the West Midlands Cystic Fibrosis (CF) Newborn Screening (NBS) service we have reviewed the nutritional outcomes of children diagnosed with CF by our laboratory between November 2007 and October 2014. This involved reviewing the height and weight measurements taken at routine CF out-patient clinics in the first two years of life for all children diagnosed with CF within this period. This service review highlighted variation in the nutritional outcomes in these children.
We know want to use the anonymised height and weight data to see if we can create a mathematical model to predict nutritional outcome in the first two years of life in a child with CF using only information that is available at the first clinic appointment (birth weight, immunoreactive trypsin, sweat chloride and faecal elastase). All the data used will be completely anonymised and no identification of patients will be possible. If a model can predict nutritional outcomes then this could potentially become a useful tool for clinicians to identify children likely to have poor nutritional outcomes.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
16/SC/0489
Date of REC Opinion
8 Sep 2016
REC opinion
Favourable Opinion